My research focuses on the identification of compounds which induce the growth of otherwise unculturable bacteria. These compounds are isolated from "helper" organisms from the same environment which induce growth in co-culture.

Publications:

D'Onofrio A., Crawford J.M., Stewart E.J., Witt K., Gavrish E., Epstein S.S., Clardy J., Lewis K. (2008). Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria. Submitted.

Lan Xu, Youhoon Chong, Inkyu Hwang, Anthony D'Onofrio, Kristen Amore, G. Peter Beardsley, Chenglong Li, Arthur J. Olson, Dale L. Boger, and Ian A. Wilson. (2007). Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase. J. Biol. Chem. 282: 13033-13046.

Correia, F., D'Onofrio, A., Rejtar, T., Li, L, Karger, B., Makarova, K., Koonin, E. and Lewis, K. (2006). Kinase Activity of Overexpressed HipA is Required for Growth Arrest and Multidrug Tolerance in Escherichia coli. Journal of Bacteriology. 24:8360-8367.